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Dec 29, 2025
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HONR 46200 - Protein Design With FoldIt
Credit Hours: 3.00. The protein folding problem is a grand challenge in biology. How does a protein’s amino acid sequence dictate its three-dimensional structure? FoldIt is an online game in which players determine the most stable folded structure of hypothetical proteins that have been predicted by unique computer algorithms to perform specific functions in the cell. Students in this course will be introduced to the mechanics of the FoldIt software to fold computer-predicted proteins into their native structures as well as design novel proteins that can bind and deactivate the COVID-19 spike protein.
Learning Outcomes
1. Demonstrate knowledge of the fundamental principles underlying protein folding and design.
2. Demonstrate knowledge of the protein structure prediction and design problems.
3. Design novel 3D protein structures using the FoldIt software.
4. Develop responsible and ethical research practices.
5. Read, summarize, and analyze scientific research articles.
6. Construct a literature review.
7. Create, present, and evaluate scientific research posters.
8. Develop strategies to translate research to the general public.
9. Critically reflect upon and articulate their learning and growth as a researcher.
Credits: 3.00
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